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Assuming an common promoter length of about 1 kb the promoter of TFC1 will overlap with the coding sequence of YlTPS1 and viceversa. This neighborhood with each other with their reverse transcription route describes the failures to disrupt YlTPS1 with insertions situated in close proximity to the 59end of its coding sequence as these might interfere with expression of YlTFC1 and outcome in lethali
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