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. Cytokines and co-stimulatory molecules of the innate immunity guide T helper cell activation and differentiation . TH1 response is associated with inflammation and autoimmunity, the TH2 response with IgE-mediated allergy. TREG cells confer suppressive activity on TH1 and TH2. Immunoglobulin class switching recombination exchanges the constant region of the antibody. It is induced either T helper
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