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t in the absence of JNK1, viral burden may well be enhanced because of a lack of apoptosis, nonetheless we observed decreased viral burden in JNK1 2/2 mice. MLK3 2/2 mice, a kinase upstream of JNK1, display enhanced Influenza A burden resulting from enhanced epithelial cell survival and viral replication. The cause for the discrepancy with these information and our findings is unclear. Many resear
L/6 mice. All procedures have been approved by the Institutional Animal Care and Use Committee in the University of Connecticut Wellness Center. Briefly, brains had been removed from decapitated mouse pups. Just after removing all meninges, the cortices were dissected, chopped into fine pieces, and enzymatically digested making use of a papain neural tissue dissociation kit in line with manufactur
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