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hat the overexpression of this CFPIQ motif may well competitively inhibit CaM interactions with Rem2. Certainly, when YFP-Rem2 was co-expressed with this motif, redistribution in response to stimulation with 25 mM glutamate/ 2.five mM glycine was attenuated. The outcomes recommend that following NMDAR-dependent Ca2+ influx, Ca2+-CaM binds the region of Rem2 around residue L317, major to its redist
SecinH3 pretreatment did not drastically attenuate the acute ADP-dependent signaling of either the P2Y1 or P2Y12 purinoceptor. As a way to examine receptor desensitization and resensitization platelets have been pretreated with ADP to desensitize receptor responses, then permitted to recover inside the presence of apyrase added to eliminate desensitizing ADP to examine resensitization of responses
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